We license various intellectual properties (patents and/or know-how) to our partners.

As for the innovative licenses which we expect can be commercialized, we propose the originality and effectiveness of the license-related researches through our workshop activities, etc.
In our licensing business, we mainly receive the fee based on a contract and the fixed royalty from the sales on The R&D-based-commercialized products.

On going project
Therapeutic products using BDNF for periodontal disease
We have been developing these products with DENTSPLY international Inc (U.S.A.). We have gained the fixed research fund for 5 years, and already signed up an agreement for the royalty after commercializing and selling. Researches have reported that BDNF promote the parodontium regeneration. Now we are researching a new treatment for periodontal disease. The new treatment is to mix BDNF with carriers and replant them　into destroyed parodontium. Periodontal disease is reportedly a common disease that 80% people over 30 years old suffer from. This disease deteriorates your parodontium such as periodontal ligaments and alveolar bones.
Candid Projects looking for a partner
①Serum-free culture medium :STK2™、NNK2 TM™
We newly-developed serum-free culture medium for the human MSC, which doesn’t contain the animal serum, and has a high level safety because it is free from BSE (bovine spongiform encephalopathy).
STK2 TM allows cells to proliferate much more than the commercial serum-free culture medium, and is available for cell culture (ex. COS7, C2C12, 10T1/2, CHO).
NNK2TM contains the bactericidal peptide. That helps us cultivate without antibacterial agent.
②Anti-Bacterial Peptides
These are the synthesized peptides based on the Anti- bacterial peptides from mammals, and have three advantages. 1)These peptides have as much antibacterial spectrum as antifungal compound (athlete’s foot remedy is representative) does, 2) have less cell toxicity than antifungal compound does, 3) have less opportunities for emergence of resistant bacteria than antifungal compound does. Also, in the cell culture field, these peptides have its own advantage that these help greatly promote the cell growth and cell ossification. These advantages are seen only in these peptides, not in any other commercial antibacterial agents.
③Cancer Diagnostic Kit :Saki(Substrate of Aurora Kinase)
Saki is the phosphorylated protein which helps us to find cancers. As this can be applied to various kinds of cancers (lung cancer, thyroid cancer, breast cancer, colonic cancer, uterine cancer, cancer of oral cavity). We expect this as a kit which improves the accuracy of diagnosis.

④Radiation Damage Diagnostic Kit :Abitan™
AbitanTM is the system (under development) using the fact that LyGDI protein, in lymphocytes in the blood, shows various degradation patterns depending on the bombed radiation dose. By using the specific antibody, we can detect as much as 0.05mSv bombed amount.
⑤Cavity Prevention Medicine:Aml(Automutanolysin）
Aml is the enzyme which performs bacteriolysis specifically against cavity bacteria only (St. mutans and St.sobrinus ). Aml doesn’t break the environment of oral resident bacterium,because of it specific bacteriosis. We expect it as the future cavity prevention medicine compared to fluorine and xylitol.
⑥Cell adhesive material:ConA (Concanavalin A）
ConA is one of the plant lectins and protein with the cell initial attachment promotive effect. And this also has the bone differentiation promotive effect as well as adhesive action. Therefore, we expect it to be applied to the implant and the artificial bone technologies.
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